In 400 AD, Hypatia writes commentaries on Diophantus and Apollonius. She is the first recorded female mathematician and she distinguishes herself with remarkable scholarship. She becomes head of the Neo-Platonist school at Alexandria.
Raphael even includes Hypatia in his masterpiece Phillosphy, or School of Athens, shown above. This painting features the greatest minds in history up to the time of Raphael.